It is somewhat unusual for an OTC drug to be withdrawn from the market as a result of safety concerns, rather than market forces, though it does happen occasionally. For example, phenylpropanolamine was removed from sale in the United States over concern regarding strokes in young women.[27] A study has been done examining consumer's perceptions about the risk of and access to nonprescription medication.

For example, many drugstores have moved products containing pseudoephedrine, an OTC product, into locations where customers must ask a pharmacist for them. A prescription is not required; the change has been made in an effort to reduce methamphetamine production. Since the passage of the Illinois Methamphetamine Precursor Control Act and the subsequent federal Combat Methamphetamine Epidemic Act of 2005, the purchase of pseudoephedrine is restricted. Sellers of pseudoephedrine must obtain and record the identity of the purchaser and enforce quantity restrictions. After initial attempts to control methamphetamine use (by requiring documentation of sale with government issued ID as well as limits on the quantity an individual could purchase) failed to realize meaningful reductions in methamphetamine use and production, Mississippi passed House Bill 512 in the State Senate on February 2, 2010 "to require a prescription from a licensed medical professional to purchase over-the-counter medicines with pseudoephedrine, ephedrine, or any other precursor chemical that can readily and illicitly be converted into methamphetamine, methcathinone or any active/scheduled analogs of phenylethylamines/​​amphetamine.

People with cardiovascular disease have an increased risk of developing heart-related issues from taking NSAIDs.

Find information on the vitamins and minerals the body needs to work best, and tips on supplement safety. 

To be safe, green coffee extract should be avoided by people who are pregnant or breastfeeding, who have heart disease or high blood pressure, or diet supplement who are taking anti-anxiety medication.

This is based on the consistent clinical experience of practitioners familiar with intermittent fasting. [weak evidence]

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The FDA requires OTC products to be labeled with an approved "Drug Facts" label to educate consumers about their medications. The labels comply to a standard format and are intended to be easy for typical consumers to understand.

Intermittent fasting has become one of the most popular and possibly easiest means for weight loss and better health.

Consider talking with a healthcare professional before using NSAIDs for an extended period, and do not take different types of NSAIDs simultaneously.

Over-the-counter weight loss supplements are not regulated by the Food and Drug Administration (FDA) as drugs, and do not require premarket review or approval by the FDA, instead placing the responsibility on the supplement manufacturers to ensure that their products are safe and the claims made are truthful and not misleading.

How it works: More recent studies suggest that garcinia extract, which comes from a fruit native to Indonesia, can reduce a fat-producing enzyme called citrate lyase and increase levels of serotonin, thus potentially helping to reduce sugar cravings, says Sopczak — but most of these studies have been conducted in animals.

Overall effectiveness: While caffeine alone won't likely make you lose weight, it may be an effective addition to your overall weight loss plan, says Sopczak. 

Understand that hunger comes and goes in waves and is a natural feeling. It seems we have been trained to fear hunger and avoid it at all costs. But hunger is a natural feeling that we can learn to acknowledge and then ignore. You may find it goes away just as quickly as it came on.